Social Pharmacy in Health Care

The study of marketing opportunities for the use of the raw material of feverfew (Tanacetum parthenium L.) in the pharmacotherapy of musculoskeletal system diseases

O. M. Yevtushenko, O. A. Ruban, M. I. Velia, I. V. Kovalevska — Thu, 02 May 2024 00:00:00 +0300

Aim. To form a modern idea of the market structure and trends in the consumption of drugs for the pharmacotherapy of rheumatoid arthritis, to determine the possible potential for use of plant raw material of feverfew (Tanacetum parthenium).

Materials and methods. The study was conducted using the structural analysis, logical and graphical methods, and marketing analysis methods.

Results. It was found that in the pre-war period the market for drugs affecting the musculoskeletal system developed quite vigorously – its growth rate in the period of 2020-2021 ranged from 16 to 29 % in natural units and from 20 to 30 % in monetary terms. According to the structure of producing countries, the market was significantly import-dependent. The market for synthetic drugs was quite saturated, represented by various dosage forms – tablets, powder for suspension, injection solutions (ampoules), granules, capsules, sachets, alcohol solutions, oil solutions, suppositories, oral suspensions, transdermal patches, gels, ointments. The research was conducted taking into account the study of marketing opportunities for the use of the raw material of Tanacetum parthenium in the pharmacotherapy of diseases of the musculoskeletal system since this raw material had certain advantages compared to synthetic analogs. It should be noted that the market of herbal medicines for the treatment of the musculoskeletal system diseases or the prevention of their manifestations is very limited and is represented by a minimum number of product items and one representative of the medicinal flora – Symphytum officinale. In addition, 90 % of the market for this group of drugs belongs to foreign manufacturers. Although research of the market for biological supplements indicates a certain demand for products based on the medicinal plant raw material.

Conclusions. Based on the trends identified, we can state the positive development of the market for drugs that affect the musculoskeletal system, the prospects for the development of drugs based on the medicinal plant raw material, including Tanacetum parthenium.

The analysis of affordability of medicines with the capillary stabilizing effect in Ukraine

Thu, 02 May 2024 00:00:00 +0300

Aim. To analyze the range, price dynamics and affordability indicators of capillary stabilizing medicines at the pharmaceutical market of Ukraine for the period of 2020-2023.

Materials and methods. The study object was the indicators of price and consumption of medicines in the group “Angioprotectors” (ATC code C05) within 2020-2023. To analyze the availability of drugs with the capillary stabilizing action presented at the pharmaceutical market of Ukraine, data from the State Register of Medicines of Ukraine, on-line Compendium, as well as data from the drug market research of the “Proxima Research” system, such online resources as Apteki.ua, Tabletki.ua, Liky-control were used. To process the information, we used modern methods of analysis, in particular generalization and systematization of information, comparison and methods of mathematical and statistical calculations.

Results. According to the results of the structural analysis of the range of capillary stabilizing medicines in groups C05C A “Bioflavonoids” and C05C X “Other capillary stabilizing medicines”, it was determined that 10 INNs of medicines were registered at the pharmaceutical market of Ukraine. Most of the medicines in the study group (57%) were of domestic production. The medicines analyzed were presented in 9 dosage forms; among them tablets, capsules and gels predominated. Individual and aggregate price indices (PI) for group C05C were calculated, they were: PI 2021/2020 = 1.10, PI 2022/2021 = 1.15, PI 2023/2022 = 1.20. In general, during the study period, price increases were observed by about 50 %, and up to 80 % for individual items. An internal referencing of prices for capillary stabilizing medicines was conducted by 9 reference groups. Prices for medicines in the form of gels and ointments were compared for primary packaging, and for tablets and capsules – per unit of dosage form. The minimum, maximum and average prices in each group and for individual trade names were determined. The analysis of price liquidity indicators (C_liq) showed that most medicines had C_liq in the range from 0.0 to 0.5 or were slightly higher. Corvitin® (BCPP, Ukraine) had the highest solvency adequacy index C_a.s= 0.064. For other medicines of the study group in the form of tablets, capsules, and gels, C_a.sranged from 0.001 to 0.03.

Conclusions. The analysis of the structure of the range of capillary stabilizing medicines at the Ukrainian pharmaceutical market within 2020-2023 has been performed. The indicators characterizing the price situation of these medicines and their affordability for patients have been calculated. According to the results of the study conducted, the indicators of the price liquidity and adequacy of solvency of medicines in this group are in the range of sufficiently high affordability throughout the period analyzed.

The comparative analysis of the economic availability of antihypertensives from the group of beta-blockers in Ukraine

N. V. Malanchuk, M. B. Demchuk, O. O. Pokotylo, A. B. Tyzhai — Thu, 02 May 2024 00:00:00 +0300

Aim. To conduct comparative studies of the economic availability of beta-adrenergic blocking agents at the domestic pharmaceutical market.

Materials and methods. Systematic, comparative, graphic, statistical and marketing research methods were used. The analysis of economic availability of medicines of beta-adrenergic receptor group (ATC code C07) registered in Ukraine in 2022-2024 was performed based on the results of calculation of the average retail price chain index (Ig), the indicator of solvency adequacy (C_a.s_.) and the affordability index (D).

Results. The highest value of the average retail price chain index for January 2022/2023 and January 2023/2024 for medicines of C07 group of ATC was calculated for carvedilol, atenolol and combinations of atenolol with other diuretics. A slight decrease in the Ig index was recorded for nebivolol, bisoprolol, betaxolol and sotalol. The high C_a.s_. index of bisoprolol, carvedilol, atenolol and metoprolol was due to the fact that there were 53 trade names in the Register of Medicines reimbursed under the terms of the “Affordable Medicines” government program. The calculated values of the D index for the drugs studied were greater than one. It is considered acceptable for consumers and determines high economic availability. However, the dynamics of a decrease in the overall affordability index in 2023-2024 compared to 2022-2023 indicates that the growth rate of drug prices exceeded the growth rate of wages.

Conclusions. The general trend towards a uniform increase in prices of β-blockers at the domestic pharmaceutical market has been studied. Taking into account the indicator of solvency adequacy and the affordability index, the analysis of the economic availability of the group of medicines studied makes it possible to determine the dynamics of a gradual improvement in the availability of medicines for the population, including due to the successful implementation of the government program for reimbursement of the cost of medicines by budget funds.

Conducting the energy analysis as a component of the energy management system of higher education institutions

M. P. Nosachenko, S. M. Kovalenko, T. V. Zborovska — Thu, 02 May 2024 00:00:00 +0300

Aim. To conduct the energy analysis of a higher education institution and form proposals for improving the energy management system in the context of using electricity and heat energy on the basis of a higher education institution (HEI).

Materials and methods. Informational, retrospective, based on the study of scientific literature, materials of Internet resources and own conclusions were used.

Results. One of the important elements of the organization’s energy management system is the collection of energy information and conducting the energy analysis. The collection of energy information and energy analysis of HEI, which forms the basis of the implemented energy management system, have been carried out. All sources of HEI energy to form the system of energy consumption of HEI have been determined and quantified. Data on costs and consumption of electricity and heat energy have been analyzed; it has allowed determining positive trends in energy consumption in HEI. Low-cost and medium-cost measures to preserve fuel and energy resources of HEI have been proposed within the framework of the implemented energy management system.

Conclusions. The collection of energy information and energy analysis of HEI, which forms the basis of the implemented energy management system, have been carried out. All sources of HEI energy to form the system of energy consumption of HEI have been determined and quantified. A number of effective measures have been proposed to improve the energy management system of HEI in the context of using electricity and heat energy.

The study of the state of pharmaceutical care for patients with dementia in Alzheimer’s disease in Ukraine

M. S. Fedotova, H. L. Panfilova — Thu, 02 May 2024 00:00:00 +0300

Aim. To conduct the study of the state of pharmaceutical care for patients with dementia in Alzheimer’s disease in Ukraine.

Materials and methods. Historical, graphic, systematic, logical, mathematical and statistical research methods were used. The analysis of the structure of drug consumption by cost indicators and the number of drugs according to the INN was carried out using an integrated ABC/VEN-analysis, which was based on the distribution of drugs using the formal and expert approach to assessing their clinical value in the treatment of patients.

Results. According to the data of the VEN-analysis using the formal approach (availability of drugs in the relevant regulatory framework), drugs with V status had the lowest consumption volumes (0.4 %) in contrast to the data we obtained when using an expert approach in the distribution of drugs (33.7 %). It was found that in the VEN-analysis (formal approach) the lion’s share in the structure of consumption accounted for drugs from group N – 80.9 %, and according to the data of the expert distribution of drugs, it was equal to 57.7 %. According to the integrated ABC/VEN analysis of drug consumption using the formal approach to assessing the pharmacotherapeutic significance of drugs, it was determined that there were no drugs with A/V status in the treatment of patients. The share of drugs with A/N status was 62.3 %. In turn, according to similar studies in which the expert approach was used, drugs with A/V status accounted for 30.5 % of the total consumption, and A/N was 47.1 %. In the case of using the formal approach, only 16 drugs (12.9 %) were assigned to the first category (vitally important, requiring control), and taking into account the opinion of experts on this issue – 23 (18.5 %) drugs. Category III of drugs (unimportant, not requiring control) included 78 (formal approach) and 48 (expert approach) drugs. In the structure of the total consumption, drugs of category I (formal approach in the VEN analysis) accounted for 80.4 %, and using the expert approach – 83.2 %; in category II, similar indicators were 14.7 % and 14.2 %, and in category III – 4.9 % and 2.6 %, respectively.

Conclusions. In the conditions of the inconsistency of the requirements of the national regulatory and legal framework, which regulates the pharmaceutical care with a modern vision of organizing the treatment process of patients with dementia, the issue of strengthening the cooperation between clinical pharmacists and doctors, as well as the active implementation of the results of clinical and economic studies in practical healthcare is relevant.

The analysis of medical prescriptions for patients with duodenal ulcer in hospital setting

Thu, 02 May 2024 00:00:00 +0300

Aim. To analyze medical prescriptions for patients with duodenal ulcer disease in hospital setting, to determine the compliance of the treatment with the current treatment protocols.

Materials and methods. We used 102 case histories, medical prescriptions of the Gastroenterology Department of the Clinical Regional Hospital named after M.I. Pirogov, Unified Clinical Protocol of the primary and specialized medical care “Peptic ulcer of the stomach and duodenum in adults and children”, the State Formulary of Medicines of Ukraine, the nomenclature of drugs for the treatment of duodenal ulcer, the official online resource tabletki.ua. Statistical, analytical and comparative, systematic, logical, graphic and mathematical-statistical methods were applied.

Results and discussion. As a result of the study conducted, an analysis of drug prescriptions for patients with duodenal ulcer was carried out at the premises of the Gastroenterology Department of the Clinical Regional Hospital named after M. I. Pirogov. Over a period of 1 year and 3 months, 102 patients with the main diagnosis of duodenal ulcer were treated. According to the data obtained from the histories of diseases, men (94 %) aged 30-40 years were most often ill. The average duration of bed days was 5 days. The most common concomitant diseases were pancreatitis, GERD (non-erosive, endoscopically positive), hepatitis, duodenal bile reflux, Oddi sphincter dysfunction (pancreatic type). Two groups of drugs were prescribed according to the ATC classification for pathogenetic and symptomatic treatment: group A – drugs affecting the digestive system and metabolism (71.43 %) and group J – antimicrobial drugs for systemic use (28.57 %). Among the producing countries, foreign-made drugs prevailed – 62.4 %. During the study period, doctors prescribed 63 active substances by INN and 109 drugs by TN. In accordance with the Unified Clinical Protocol, the number of INN drugs was 18, 39 drugs by TN, and the State Formulary included drugs of 48 INN and 80 TN. During the study period, 24 drugs by TN for the pathogenetic treatment (eradication therapy) and 18 drugs by TN for the symptomatic treatment were prescribed. The prescription of drugs for the pathogenetic and symptomatic treatment was scientifically substantiated and included in the current normative documentation for the provision of patients with duodenal ulcer. When conducting the eradication therapy the leading drugs were Omeprazole (66 prescriptions), De-nol (55 prescriptions), Ezonexa (29 prescriptions), Controlok (26 prescriptions), Pilobact Neo (24 prescriptions). To prevent dysbiosis, such drugs as Enterol (8 prescriptions), Enterogermina forte (7 prescriptions) were most often prescribed. To relieve the symptoms of duodenal ulcer, Mebsyn Retard (24 prescriptions), Trimspa (19 prescriptions), Neospastil (17 prescriptions) were applied.

Conclusions. Therefore, the medical care of patients in hospital setting is expedient and corresponds to the current Treatment Protocols.

The study of the level of awareness of pharmacists on vaccination against human papillomavirus and the role of pharmacists in the prevention of cervical cancer

Thu, 02 May 2024 00:00:00 +0300

Aim. To study the awareness of pharmacists about vaccination against human papillomavirus (HPV) and the role of pharmacists in the prevention of cervical cancer.

Materials and methods. The results of a survey of pharmacists on vaccination against HPV and the role of pharmacists in the prevention of cervical cancer are presented. The data analysis is accompanied by the use of systematic, sociological (questionnaire survey) analysis, comparison and generalization.

Results. A pharmacist plays an important role in providing information to the public about human papillomavirus, vaccination against human papillomavirus and the risk of cervical cancer. According to the results of the survey, it has been determined that the majority of respondents consider it appropriate for pharmacists to participate in programs that will help to raise public awareness about the human papillomavirus, the importance of HPV vaccination and the risk of cervical cancer. However, only about 20 % of doctors provide this information to their patients, while almost 80 % do not. Low information awareness of the population has been identified as a key factor affecting vaccination readiness.

Conclusions. Based on the analysis, it has been found an insufficient level of knowledge about human papillomavirus among pharmacists to inform the population, as well as a lack of willingness to participate in activities aimed at raising public awareness about vaccination against papillomavirus.

Problems of creating an effective system of health technology assessment at the early stages of the drug life cycle

V. M. Nazarkina, A. S. Nemchenko, I. M. Podolsky, M. M. Babenko, T. M. Koba — Thu, 02 May 2024 00:00:00 +0300

Aim. To study modern approaches to the formation and functioning of the Horizon Scanning (HS) system and early health technology assessment (HTА), in particular, for the treatment of rare diseases with significant unmet medical needs.

Materials and methods. The analysis, systematization and synthesis of data from scientific publications, analytical reports, guidelines, information from official websites of regulatory authorities, HTА and HS agencies were used.

Results. The analysis of the theoretical foundations and regulatory support for the processes of forming an effective HS system at the early stages of the life cycle has been performed. HS systems, the so-called “early awareness and alert systems”, are aimed at identifying, filtering and prioritizing new and innovative technologies with a significant predicted impact on health, costs, society and the healthcare system in order to inform policy makers, purchasers and healthcare providers or improve early access. The HS system allows for proactive planning and decision-making on the use and reimbursement of new medicines based on preliminary assessments of budgetary impact and clinical efficacy.

Conclusions. For the national HTA system, which currently is at the stage of development, it is important to adapt positive international experience in this area and provide functionality for HS, early assessment, early dialogue, managed access with the development of the evidence base. It is advisable to apply the “light” model and join the international cooperation in this area.