The study of the impact of rehabilitation measures on the dynamics of cognitive disorders in Parkinson’s disease

Authors

DOI:

https://doi.org/10.24959/sphhcj.22.250

Keywords:

Parkinson’s disease; cognitive disorders; Mini-mental State Examination; Mattis dementia scale.

Abstract

Aim. To assess the level of cognitive impairment and its dynamics over 6 months in Parkinson’s disease.

Materials and methods. The study involved 31 people with Parkinson’s disease, including 15 women and 16 men. The average age of patients at the beginning of the study was 65.1 (m = 0.54). The duration of the disease varied from 3 to 8 years. The Mini-mental State Examination (MMSE) and the Mattis dementia scale were used to study cognitive functions. The Wechsler Adult Intelligence Scale (WAIS) was used to assess attention. The study of speech was conducted using the free and directed association test, and visual-spatial functions were studied using the “drawing clock” test. The visual memory test from the SKT test battery was used to assess memory, and affective disorders were studied using the Beck Depression Scale. Depression was diagnosed according to the ICD-10 criteria. The vegetative disorders were assessed using the autonomic disorders scale. The results obtained were processed using mathematical statistics methods.

Results. The data obtained in the course of the study allow us to state the stability in disturbance of the vegetative function. The affective symptoms in patients with mild cognitive impairment were improved. In patients with moderate and severe cognitive impairment, affective symptoms remained stable. There were also no significant changes in the Mattis dementia scale, the Beck Depression Scale, the coding test, visual-spatial functions, grammatical associations, semantics and phonetics.

Conclusions. The studies showed that after the introduction of a comprehensive rehabilitation program for 6 months there were minor improvements indicating the need for further improvement and implementation.

Author Biographies

A. V. Nevelika, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Sciences in Physical Education and Sports (Ph.D.), senior lecturer at the Department of Physical Rehabilitation and Health, National University of Pharmacy

O. M. Myatyha, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Sciences in Physical Education and Sports (Ph.D.), associate professor of the Department of Physical Rehabilitation and Health, National University of Pharmacy

L. V. Karabut, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Medicine (Ph.D.), associate professor of the Department of Clinical Laboratory Diagnostics of the National University of Pharmacy

H. L. Lytvynenko, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Medicine (Ph.D.), associate professor of the Department of Clinical Laboratory Diagnostics of the National University of Pharmacy

References

Demchenko, A. V., Biriuk, V. V. (2020). Zaporozhskyi medytsynskyi zhurnal, 22 (2 (119)), 250-255. doi: 10.14739/2310-1210.2020.2.200630.

Kozolkin, O. A., Revenko, A. V. Miedviedkova, S. O. (2017). Khvoroba Parkinsona : suchasni aspekty diahnostyky i likuvannia. (2nd ed.). Zaporizhzhia: ZDMU, 158.

Kryzhanovskyi, S. A., Shalenko, O. V., Karasevych, N. V., Karaban, Y. N. (2017). Ukrainskyi nevrolohichnyi zhurnal, 4, 19-24.

Levyn, O. S., Artemev, D. V., Bryl, E. V., Kulua, T. K. (2017). Praktycheskaia medytsyna, 1 (102), 45-51.

Nodel, M. R., Kovrov, H. V. (2017). Nevrolohiia, neiropsykhiatriia, psykhosomatika, 9 (4), 88-94

Pashkovskyi, V. M., Yaremchuk, O. B., Krychun, I. I., Vasylieva, N. V. Bilous, I. I. (2017). Klinichna ta eksperymentalna patolohiia, 16, (3), 31-35.

Slobodin, T. M., Starovoitova, H. O. (2016). Skhidno-yevropeiskyi zhurnal khvoroby Parkinsona y ekstrapiramidnykh zakhvoriuvan, 2 (2), 10-20.

Starovoitova, H. O. (2019). Kliniko-patohenetychni osoblyvosti riznykh fenotypiv khvoroby Parkinsona na osnovi spivstavlennia rukhovykh, nemotornykh proiaviv ta osobystisnykh rys khvorykh. Dissertation. Kyiv.

Starovoitova, H. O., Deviniak, O. T., Slobodin, T. M. (2018). Nevrolohiia ta neirokhirurhiia. Skhidna Yevropa, 3 (8), 426-437.

Aleksovski, D., Miljkovic, D., Bravi, D., Antonini, A. (2018). Disease progression in Parkinson subtypes: the PPMI dataset. Neurol Sci., 39 (11), 1971-1976. doi: 10.1007/s10072-018-3522-z.

Kotvitska, A. A., Prokopenko, O. S. (2017). The study of the prevalence and incidence of Parkinson’s disease in different world regions. Social Pharmacy in Health Care, 3 (4), 76-82. doi: https://doi.org/10.24959/sphhcj.17.93.

Namura, P. (2019). The Cognitive Neuropsychiatry of Parkinson’s Disease. (1st ed.). Kindle Edition, 248. doi: 10.7551/mitpress/9780262016087.001.0001.

Rajput, A. H., Rajput, M. L., Ferguson, L. W., Rajput A. (2017). Baseline motor findings and Parkinson disease prognostic subtypes. Neurology, 11 (89(2)), 138-143. doi: 10.1212/WNL.0000000000004078.

Santangelo, G., Garramone, F., Baiano, C., D’Iorio, A., Piscopo, F., Raimo, S., Vitale, C. (2018). Personality and Parkinson’s disease: A meta-analysis. Parkinsonism Relat Disord., 49, 67-74. doi: 10.1016/j.parkreldis.2018.01.013.

Tappakhov, A. A., Popova, T. E., Nikolaeva, T. Y., Schnaider, N. A., Petrova, M. M., Sapronova, M. R. (2017). Neuropsychological pattern of Parkinson’s disease. Neurology, Neuropsychiatry, Psychosomatics, 9 (4), 82-87. doi: 10.14412/2074-2711-2017-4-82-87.

Titova, N., Chaudhuri, K. R. (2017). Personalized medicine in Parkinson’s disease: time to be precise. Movement Disorders, 32 (8), 1147. doi: 10.1002/mds.27027.

Zafar, S., Yaddanapudi, S. S. (2020). Parkinson Disease. Treasure Island (FL): StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK470193/.

Published

2022-05-26

Issue

Section

Social medicine and pharmacy: past, present and development prospects