Aspects of the retinoid use in the pharmaceutical practice

Authors

  • O. V. Shtrimaitis Municipal Institution of Higher Education «Rivne Medical Academy» of Rivne Region Council, Ukraine, Ukraine https://orcid.org/0000-0002-1305-2251
  • O. S. Kukhtenko National University of Pharmacy of the Ministry of Health of Ukraine, Kharkiv, Ukraine

DOI:

https://doi.org/10.24959/sphhcj.22.261

Keywords:

retinoids; adapalene; tazarotene; local action; acne; psoriasis.

Abstract

Aim. To analyze the use of retinoids in the pharmaceutical practice of Ukraine and the world and determine the prospects for the development of domestic medicinal products containing retinoids.

Materials and methods. The study objects were local and systemic medicines containing active substances belonging to retinoids by their composition (adapalen, tazarotene, tretinoin, acitretin, isotretinoin, etc.). For the analysis of the recent research and publications the methods of scientific analysis were used; they contributed to the comparison, analysis, generalization and systematization of literature data. To achieve the goal, generally accepted research methods were used; they contributed to an objective assessment of the analysis of the pharmaceutical market.

Results. Based on the results of the studies conducted, a brief description and classification by generations of the group of active substances belonging to retinoids is given. The list of diseases for which these substances are used in world therapeutic practice has been determined. Data regarding the need to use modern techniques to preserve the therapeutic properties of retinoids have been obtained. The pharmaceutical market of Ukraine has been studied for the presence of medicinal products containing retinoids (6 products of local action out of the range of only 9 products). Dosage forms (gels and lotions) for the treatment of dermatological diseases in Ukraine have been identified. It has been found that adapalene has a greater share of medicines at the pharmaceutical market of Ukraine as local agents.

Conclusions. The studies have shown the absence of domestic medicinal products containing retinoids for the treatment of a number of dermatological diseases at the pharmaceutical market of Ukraine. Based on the research results, the relevance of further studies on the development of retinoid-containing products for use as local therapy has been determined.

References

Retinoids: A Journey from the Molecular Structures and Mechanisms of Action to Clinical Uses in Dermatology and Adverse Effects / S. Khalil et al. Journal of Dermatological Treatment. 2017. Vol. 28 (8). DOI: https://doi.org/10.1080/09546634.2017.1309349.

Болотная Л. А., Сидельник В. М., Осипенко Т. С. Ретиноиды в практике дерматовенеролога. Клінічна імунологія. Алергологія. Інфектологія. 2012. Т. 1. С. 10-13.

Zasada M., Budzisz E. Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy Dermatol Alergol. 2019. Vol. 36 (4). P. 392-397. DOI: https://doi.org/10.5114/ada.2019.87443.

Wiegand U. W., Chou R. C. Pharmacokinetics of acitretin and etretinate. Journal of the American Academy of Dermatology. 1998. Vol. 39. P. S25-S33.

Boisnic S., Licu D., Ben Slama L., Branchet-Gumila M. C., Szpirglas H., Dupuy P. Topical retinaldehyde treatment in oral lichen planus and leukoplakia. Int J Tissue React. 2002. Vol. 24 (4). P. 123-30.

Tufts Health Plan. Pharmacy Medical Necessity Guidelines: Acne and Rosacea Medications (October 1, 2021).

National Library of Medicine. URL: https://dailymed.nlm.nih.gov/dailymed/.

Uray I. P., Dmitrovsky E., Brown P. H. Retinoids and rexinoids in cancer prevention: from laboratory to clinic. Semin Oncol. 2016. Vol. 43 (1). P. 49-64. DOI: https://doi.org/10.1053/j.seminoncol.2015.09.002.

Tang X. H., Gudas L. J. Retinoids, retinoic acid receptors, and cancer. Annu Rev Pathol. 2011. Vol. 6. P. 345-364. DOI: https://doi.org/10.1146/annurev-pathol-011110-130303.

Melis M., Tang X. H., Trasino S. E., Gudas L. J. Retinoids in the Pathogenesis and Treatment of Liver Diseases. Nutrients. 2022. Vol. 14 (7). P. 1456. DOI: https://doi.org/10.3390/nu14071456.

Miyabe Y., Miyabe C., Nanki T. Could retinoids be a potential treatment for rheumatic diseases? Rheumatol Int. 2015. Vol. 35 (1). P. 35-41. DOI: https://doi.org/10.1007/s00296-014-3067-2.

Njar V. C., Gediya L., Purushottamachar P., Chopra P., Belosay A., Patel J. B. Retinoids in clinical use. Med Chem. 2006. Vol. 2 (4). P. 431-438. DOI: https://doi.org/10.2174/157340606777724022.

Gonçalves A., Estevinho B. N., Rocha F. Formulation approaches for improved retinoids delivery in the treatment of several pathologies. Eur J Pharm Biopharm. 2019. Vol. 143. P. 80-90. DOI: https://doi.org/10.1016/j.ejpb.2019.08.014.

Гладух Є. В., Рубан О. А., Сайко І. В. Промислова технологія лікарських засобів : базовий підруч. для студентів вищ. навч. фармацевт. закладу (фармацевт. ф-тів). Харків : НФаУ ; Оригінал, 2016. 632 с.

KEGG DRUG Database. URL: http://www.kegg.jp/kegg/drug/.

Державний реєстр лікарських засобів України. URL: http://www.drlz.com.ua/.

Компендіум – лікарські препарати. Довідник лікарських засобів в Україні № 1. URL: https://compendium.com.ua/uk/atc/.

Державний формуляр лікарських засобів. Київ, 2021. Вип. 13. 1288 с.

Published

2022-11-11

Issue

Section

Organizational and socio-economic bases of pharmaceutical activities