Analysis of evidence-based data and the information support of pharmaceutical care for preqnant women


  • N. M. Maksymovych Lviv National Medical University named after Danylo Halytsky, Ukraine



evidence-based medicine, nausea and vomiting in pregnancy, economic costs of treatment of nausea and vomiting in pregnancy, ondansetron


The article presents the evidence-based data and the results of systematic analysis of the national and English publications, regulation documents, PubMed, Cochrane systematic reviews on the problem of the rational pharmacotherapy of nausea and vomiting of pregnant women (NVP). The range of drugs used for the evidence-based treatment of NVP has been analyzed. The economic costs of the drug regimen for ondansetron as the second-line drug treatment have been evaluated. The analysis of 32 official instructions on specific drugs in NVP has been carried out. It has been determined that the insufficient data or the lack of information about doses, duration of administration in NVP for such drugs as ondansetron, metoclopramide, promethazine, doxylamine complicate the correct dosing and the regimen in pregnancy. The necessity of addition and correction of official instructions concerning the dose, duration of administration in NVP has been substantiated. It has been shown that there is a need to extend the range of the registered drugs, in particular by the combination of doxylamine succinate and pyridoxine hydrochloride recommended by the FDA and commonly prescribed for pregnant women in many countries for the evidence-based effective treatment of NVP.

Author Biography

N. M. Maksymovych, Lviv National Medical University named after Danylo Halytsky

Assistent prof.


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