The rheological studies of the gel base with a dense extract from burdock

Ie. V. Gladukh, Anael Marcelle Seguy, N. O. Nicolaychuk

Abstract


A rapid development of civilization and deterioration of the ecological condition of the environment lead to increase in allergic diseases. The studies conducted in several regions ofUkrainehave shown that in industrial centers 10–20 % of the population suffer from allergic diseases, and only 2–4 % in rural areas. To solve the problems researchers and practical surgeons pay more attention to drugs of the natural origin containing a significant number of biologically active compounds, some of them are with the reparative and anti-inflammatory activity.

Aim. To conduct the studies in developing the gel composition containing a dense extract from burdock for its use in dermatology.

Materials and methods. Development of a new drug is based on the general methodological approach to pharmaceutical development taking into account the requirements for a dosage form. To assess the structural and mechanical properties of the gel developed the rheological parameters were determined using a Rheolab QC rotary viscometer (Anton Paar,Austria) with coaxial cylinders CC27/S-SN29766.

Results. The concentration of hydroxymethylcellulose (2 %) has been determined; it provides the structural and mechanical properties required for the gel base. It has been determined that the gel base with hydroxymethyl cellulose (HMC) refers to non-newtonian flow types with plastic properties and has thixotropy. The calculated value of the HMC gel base allows predicting stability in homogenization and storage of the finished drug.

Conclusions. The rheological parameters of the gel with the burdock extract on the HMC base have been studied.

Keywords


burdock extract; gel; hydroxymethyl cellulose; structural and mechanical properties

References


Pawankar, R., Mori, S., Ozu, C., Kimura, S. (2011). Overview on the pathomechanisms of allergic rhinitis. Asia Pacific Allergy, 1 (3), 157–167. doi: 10.5415/apallergy.2011.1.3.157.

Maspero, J., Lee, B. W., Katelaris, C. H., Potter, P. C., Cingi, C., Lopatin, A. et al. (2012). Quality of life and control of allergic rhinitis in patients from regions beyond western Europe and the United States. Clinical & Experimental Allergy, 42 (12), 1684–1696. doi: 10.1111/j.1365–2222.2012.04025.x.

Segi, Anan, Nikolaichuk, N. A. (2015). Proceedings of Sovremennaia farmaciia: problemy i perspektivy razvitiia: International Scientific and Practical Conference, 2015 May 29–30 (pp. 233–236). Vladikavkaz.

Segi, Anan Marcelle, Nikolaichuk, N. A. (2015). Recipe, 6 (104), С. 59–63.

Gladukh, Ie. V., Segі, Anan Marsel’. (2015). Proceedings of Medichna nauka ta praktika na suchasnomu іstorichnomu etapі: International Scientific and Practical Conference, 2015 May 8 (pp. 122–125). Kyiv.

Gladukh, Ie. V., Seguy, Anael Marcelle. (2016). The study of pharmacotechnological parameters of burdock (Arctium lappa) leaves. Journal of Chemical and Pharmaceutical Research, 8 (1), 260–264.

Gladukh, Ie. V., Grubnik, I. M., Kukhtenko, G. P., Stepanenko, S. V. (2015). Rheological studies of water–ethanol solutions of gel–formers. Journal of Chemical and Pharmaceutical Research, 7 (4), 729–734.

Gladyshev, V. V., Kuchina, G. K., Burlaka, B. S., Biriuk, I. A. (2013). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 1 (11), 69–72.

Rogachev, I. O., Gladyshev, V. V., Burlaka, B. S., Kechin, I. L. (2011). Zaporozhskii meditsinskii zhurnal, 13 (3), 92–94.

Davtian, L. L., Vashchuk, V. A., Polishchuk, Y. P. (2013).


GOST Style Citations


1. Overview on the pathomechanisms of allergic rhinitis / R. Pawankar, S. Mori, C. Ozu, S. Kimura // Asia Pac. Allergy. – 2011. – Vol. 1, No. 3. – P. 157–167. doi : 10.5415/apallergy.2011.1.3.157.

2. Quality of life and control of allergic rhinitis in patients from regions beyond western Europe and the United States / J. Maspero, B. W. Lee, C. H. Katelaris et al. // Clin. Exp. Allergy. – 2012. – Vol. 42, Issue 12. – P. 1684–1696. doi : 10.1111/j.1365-2222.2012.04025.x.

3. Сеги Анан. Изучение процесса экстракции листьев лопуха / Сеги Анан, Н. А. Николайчук // Современная фармация: проблемы и перспективы развития: материалы V Межрегиональной науч.–практ. конф. с междунар. участием, г. Владикавказ, 29–30 мая 2015 г. – Владикавказ, 2015. – С. 233–236.

4. Сеги Aнан Mарсель. Получение экстракта листьев лопуха / Сеги Aнан Mарсель, Н. А. Николайчук // Рецепт. – 2015. – № 6 (104). – С. 59–63.

 5. Гладух, Є. В. Вибір основи при створенні мазі з густим екстрактом листя лопуха / Є. В. Гладух, Сегі Анан Марсель // Медична наука та практика на сучасному історичному етапі: матеріали міжнар. наук.–практ. конф., м. Київ 8 травня 2015 р. – К., 2015. – С. 122–125.

6. Gladukh, Ie.V. The study of pharmacotechnological parameters of burdock (Arctium lappa) leaves / Ie. V. Gladukh, Seguy Anael Marcelle // Journal of Chemical and Pharmaceutical Research. – 2016. – Vol. 8 (1). – Р. 260–264.

7. Rheological studies of water–ethanol solutions of gel–formers / Ie. V. Gladukh, I. M. Grubnik, G. P. Kukhtenko, S. V. Stepanenko // Journal of Chemical and Pharmaceutical Research. – 2015. – No. 7 (4). – Р. 729–734.

8. Исследование реологических свойств мягкой назальной лекарственной формы дилтиазема / В. В. Гладышев, Г. К. Кучина, Б. С. Бурлака, И. А. Бирюк // Актуальні питання фармацевтичної і медичної науки та практики. – 2013. – № 1 (11). – С. 69–72.

9. Сравнительные исследования структурно–механических характеристик интраназальных мягких лекарственных форм нимодипина / И. О. Рогачев, В. В. Гладышев, Б. С. Бурлака, И. Л. Кечин // Запорожский медицинский журнал. –2011. – Т. 13, № 3. – С. 92–94.

10. Давтян, Л. Л. Реологічні дослідження як основа технологічного процесу у разі створення нового лікарського засобу / Л. Л. Давтян, В. А. Ващук, Ю. П. Поліщук // Фармацевтичний журнал. – 2013. – № 4. – С. 52–58.





DOI: https://doi.org/10.24959/sphhcj.17.92

Abbreviated key title: Soc. farm. ohor. zdor.

ISSN 2518-1564 (Online), ISSN 2413-6085 (Print)