The substantiation of the technology for preparing the cream with silver citrate

Authors

DOI:

https://doi.org/10.24959/sphhcj.18.102

Keywords:

cream emulsion, veterinary drug, silver citrate, rheology, dispersion analysis, technology

Abstract

Aim. To substantiate the technology for preparing a veterinary cream with silver citrate and study the effect of the conditions of preparation on the quality of the finished product.

Materials and methods. The studies were carried out with the cream samples obtained by different methods. Emulsification was carried out using a Polytron® System PT 2500 homogenizer manufactured by Кinematica AG,Switzerland. The samples were subjected to microscopic and rheological studies.

Results. Using a Rheolab QC rheometer (Anton Paar,Austria) and the system of coaxial cylinders C-CC27/SS it was determined that by all rheological indicators the cream samples were not significantly different and had the similar profile of their rheological behavior. The samples had a low flow boundary calculated by the Casson mathematical model. It indicates easy extrusion from the tube and application on the animal’s skin surface. The samples prepared using the complete mixing technology appeared to be the most resistant to mechanical impact based on the viscosity values at infinite shear rate according to the Casson model. The samples prepared by the phase inversion technology had a lower value of the hysteresis loop area.

Conclusions. The effect of the technology for preparing the cream and the rate of emulsification on disperse and structural-mechanical parameters has been studied. It has been found that at the rate of emulsification of 5.000 rpm there are no significant changes using both the complete mixing technology and the phase inversion technology. The effect of the temperature on the disperse system stability has been studied, and the temperature range for transporting and filling the cream into tubes has been determined.

Author Biographies

Zh. M. Polova, O.O.Bohomolets National Medical University

Candidate of Pharmacy (Ph.D.), associate professor , head of the Department of Pharmaceutical and Industrial
Technology of Medicines

H. P. Kukhtenko, National University of Pharmacy

associate professor of the Industrial Pharmacy Department

Ye. V. Gladukh, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), professor, head of the Industrial Pharmacy Department

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Published

2018-03-14

Issue

Section

Social medicine and pharmacy: past, present and development prospects