The study of rheological properties and development of the technology for “Fuzipan-derma” gel for the treatment of acne

Authors

DOI:

https://doi.org/10.24959/sphhcj.18.125

Keywords:

fusidic acid, acne, gel, structural and mechanical properties, technology

Abstract

Aim. To develop the composition and technology of a new medicinal product for external use with fusidic acid; to substantiate the optimal ratio of the gelation agents selected (xanthan gum and sodium alginate) with the help of rheological studies.

Materials and methods. Generally accepted structural-mechanical, physicochemical and technological methods of research were used in the work.

Results. The previous studies proved that a stable system was obtained by introducing the alcoholic solution of fusidic acid into the gel base consisting of natural gelation agents (xanthan gum and sodium alginate). In order to create a stable gel with the given properties the experimental samples with different ratios of the gelation agents selected were studied. It was found that all samples were stable, the pH value and mechanical stability changed insignificantly. With the help of structural and mechanical studies the sample of the gel with the ratio of xanthan gum and sodium alginate of 1.5 : 0.5 was chosen. This gel had the best consumer, extrusion and technological properties. The rational technology of the gel was developed and included 5 main stages of the manufacturing process and three stages of packaging.

Conclusions. The gel for external use with fusidic acid and panthenol based on the gel composition of xanthan gum and sodium alginate in the ratio of 1.5 : 0.5, respectively, has been developed. It has been found that this composition with APIs selected is stable and has satisfactory consumer, structural, mechanical and technological properties.

Author Biographies

P. P. Baiva, National University of Pharmacy

postgraduate student of Department of Commodity Science

I. I. Baranova, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), professor, head of the Department of Commodity Science

T. V. Martyniuk, National University of Pharmacy

Candidate of Pharmacy (Ph.D), associate professor of the Department of Cosmetology and Aromology

Sv. M. Kovalenko, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), Doctor of Pharmacy (Dr. habil.), professor of the Department of Commodity Science

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Published

2018-09-05

Issue

Section

Social medicine and pharmacy: past, present and development prospects