The study of rheological properties and development of the technology for “Fuzipan-derma” gel for the treatment of acne
Keywords:fusidic acid, acne, gel, structural and mechanical properties, technology
Aim. To develop the composition and technology of a new medicinal product for external use with fusidic acid; to substantiate the optimal ratio of the gelation agents selected (xanthan gum and sodium alginate) with the help of rheological studies.
Materials and methods. Generally accepted structural-mechanical, physicochemical and technological methods of research were used in the work.
Results. The previous studies proved that a stable system was obtained by introducing the alcoholic solution of fusidic acid into the gel base consisting of natural gelation agents (xanthan gum and sodium alginate). In order to create a stable gel with the given properties the experimental samples with different ratios of the gelation agents selected were studied. It was found that all samples were stable, the pH value and mechanical stability changed insignificantly. With the help of structural and mechanical studies the sample of the gel with the ratio of xanthan gum and sodium alginate of 1.5 : 0.5 was chosen. This gel had the best consumer, extrusion and technological properties. The rational technology of the gel was developed and included 5 main stages of the manufacturing process and three stages of packaging.
Conclusions. The gel for external use with fusidic acid and panthenol based on the gel composition of xanthan gum and sodium alginate in the ratio of 1.5 : 0.5, respectively, has been developed. It has been found that this composition with APIs selected is stable and has satisfactory consumer, structural, mechanical and technological properties.
Baiva, P. P., Makarova, O. Ye., Baranova, I. I., Martyniuk, T. V. (2017). Upravlinnia, ekonomika ta zabezpechennia yakosti v farmatsii, 4 (52), 36–41. doi: 10.24959/uekj.17.36.
Baiva, P. P., Makarova, O. Ye., Baranova, I. I. (2017). Proceeding of Materialy mizhnar. nauk.–prakt. konf. do 25–richchia z dnia vidkryttia v Ukraini spetsialnosti “Promyslova farmatsiia” (pp. 15–17). Kharkiv.
Baiva, P. P., Maloshtan, L. M., Torianyk, E. L. (2013). Problemy ekolohichnoi ta medychnoi henetyky i klinichnoi imunolohii, 6, 159–167.
Diudiun, A. D., Polyon, N. N., Bashmakov, D. H., Zakharov, V. K., Lozynskaia, Y. P. (2011). Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, 2 (41), 87–91.
Diudiun, A. D., Polion, N. N., Getala, N. D. (2006). Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, 3, 38–40.
Kutasevich, Ia. F., Ogurtcova, A. N. (2007). Dermatologіia ta venerologіia, 1, 53–58.
Baranova, I. I., Baiva, P. A., Martyniuk, T. V. (2014). Farmaatsevtychna kompozytsiia “Fuzipan–derma” dlia likuvannia vuhrovoi khvoroby I–II stadii. Patent 88421 of Ukraine. MPK A 61 K 31/00. Declared 08.11.2013; published 11.03.2014, No. 5.
Baranova, I. I., Kovalenko, Sv. M., Khokhlenkova, N. V., Martyniuk, T. V., Kutsenko, S. A. (2017). Prospects of using synthetic and semisynthetic gelling substances in development of medical and cosmetic gels. Asian Journal of Pharmaceutics, 11 (1), 302–307.
Baiva, P. P., Kovalenko, S. M., Baranova, I. I., Kutsenko, S. A., Tereshchenko, L. V. (2017). Experimental research for gelection in the development of a medicine for the II degree of acne. Asian Journal of Pharmaceutical, 11 (4), 830– 833.
Shöfer, H., Simonsen, L. (2010). Fusidic acid in dermatology: an updated review. Eur. J. Dermatol., 20 (1), 6–15. doi: 10.1684/ejd.2010.0833.
Loeffler, A., Baines, S. J., Toleman, M. S., Felmingham, D., Milsom, S. K., Edwards, E. A., Lloyd, D. H. (2008). In vitro activity of fusidic acid and mupirocin against coagulase–positive staphylococci from pets. J. Antimicrob. Chemother, 62, 1301–1304. doi: 10.1093/jac/dkn398.
Percival, S. L., Emanuel, C., Cutting, K. F., Williams, D. W. (2012). Microbiology of the skin and the role of biofilms in infection. Int. Wound J., 9 (1), 14–32. doi: 10.1111/j.1742-481X.2011.00836.x.
Rieg, S., Saborowski, V., Kern, W., Jonas, D., Bruckner, В., Tuderman, L., Hofmann, S. (2014). Expression of the sweat–derived innate defence antimicrobial peptide dermcidin is not impaired in Staphylococcus aureus colonization or recurrent skin infections. Clinical and experimental dermatology, 39, 209. doi: 10.1111/ced.12189.
Baiva, P. P., Baranova, I. I, Streletz, O. P., Makarova, O. E. (2018). A study of antimicrobial activity of antimicrobial activity of “Fuzipan-Derma” Gel. Annals of Mechnikov`s Institute, 2, 36-38.
Anderson, J. D. (1980). Fusidic acid: new opportunities with an old antibiotic. Can. Med. Assos. J., 122 (7), 765–769.
Long, B. H. (2008). Fusidic acid in scin and softtissue infections. Acta Derm. Venereol., 88 (216), 14–20. doi: 10.2340/00015555-0387.
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).