The study on development of the liquid extract with the broncholytic action
DOI:
https://doi.org/10.24959/sphhcj.18.134Keywords:
combined drug, extract, technology, market percolationAbstract
Aim. To determine the extractant and the multiplicity of extraction when developing the technology of the extract by the method of percolation.
Materials and methods. To determine the optimal extraction conditions the extract was obtained using the method of percolation. Each extract was selected fractionally in DER step 1 : 1 (the drug extract ratio is the ratio of the initial material to the extract obtained). For each sample the quantitative determination was performed, and the main indicators of the process dynamics were calculated. The extraction process was carried out to obtain the total extract of DER 1 : 10. For each sample of the extract the dry residue and the basic physical and chemical characteristics were determined. The extraction process was controlled by the quantitative determination of polyphenolic compounds by spectrophotometric method of analysis.
Results. The maximum yield of the amount of phenolic compounds calculated with reference to gallic acid was observed when extracting the raw material with alcohol in the concentration of 70 %. When determining the extraction multiplicity of the raw material in the composition of the complex liquid extract based on the analysis of the dry residue and the content of polyphenolic compounds calculated with reference to gallic acid it was determined that the optimal extraction multiplicity in obtaining the liquid extract was 3.
Conclusions. Based on the studies conducted on determination of extractives in the medicinal plant raw material an effective extractant – 70 % ethyl alcohol has been identified. After analyzing the extracts of the medicinal plant raw material per the amount of extractives, dry residue and polyphenolic compounds the effective multiplicity of extraction of the total liquid extract with the broncholytic activity has been determined to be 3.
References
Maiko, D. V., Kukhtenko, O. S. (2014). Proceeding from Suchasni dosiahnennia farmatsevtychnoi tekhnolohii i biotekhnolohii: materialy IV nauk.–prakt. konf. z mizhnar. uchastiu (16–17 zhovtnia 2014) (pp. 193). Kharkiv: Vyd-vo NFaU.
Koshovyi, O. M., Kukhtenko, O. S., Kovalova, A. M., Komisarenko, A. M. (2011). Farmatsevtychnyi chasopys, 4, 39–42.
Kha, Dyk An, Kukhtenko, O. S., Gladukh, Ye. V. (2016). Development of technology for producing compound thick extract obtained by common extraction of thyme, yarrow, chamomile and eucalyptus. Proceeding from Actual Questions of Development of New Drugs: Abstracts of the XXIII-th International Scientific And Practical Conference of Young Scientists And Student (April 21, 2016) (Vol. 1, pp. 267). Kharkiv: Publishing Office.
Kukhtenko, O. S., Hladukh, Ye. V., Simonian, L. S. (2017). Upravlinnia, ekonomika ta zabezpechennia yakosti v farmatsii, 4 (52), 42–49. doi: 10.24959/uekj.17.35.
Marakhova, A. Y. (2009). Farmatsiia, 3, 52–55.
Derzhavne pidpryiemstvo “Naukovo–ekspertnyi farmakopeinyi tsentr”. (2008). Derzhavna Farmakopeia Ukrainy. 1st ed., 2nd suppl. Kharkiv: RIREH, 620.
Derzhavne pidpryiemstvo “Naukovo–ekspertnyi farmakopeinyi tsentr”. (2009). Derzhavna Farmakopeia Ukrainy. 1st ed., 3rd suppl. Kharkiv: RIREH, 280.
Burda, N. Ye., Zhuravel, I. O., Kyslychenko, V. S., Diemokhin, V. B. (2011). Ukrainskyi medychnyi almanakh, 4 (1), 45–46.
Voloshyna, A. A., Kyslychenko, V. S., Zhuravel, I. O., Burda, N. Ye. (2012). Ukrainskyi zhurnal klinichnoi ta laboratornoi medytsyny, 7 (4), 202–203.
Koshovyi, O. M., Kukhtenko, O. S., Kovalova, A. M., Komisarenko, A. M., Vynnyk, O. V., Tsekhovskyi, M. V. (2010). Zbirnyk naukovykh prats spivrobitnykiv NMAPO im. Shupyka, 19 (3), 632–637.
Koshovyi, O. M., Kukhtenko, O. S., Kovalova, A. M., Komisarenko, A. M., Vynnyk, O. V., Sholom, Yu. H. (2010). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, ХХІІІ (1), 47–49.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
