DOI: https://doi.org/10.24959/sphhcj.19.170

The study of the expediency of developing a new semi-solid drug based on the extract of Scutellaria baicalensis

G. D. Slipchenko, O. A. Ruban, T. Ye. Kolisnyk

Abstract


Aim. To conduct the marketing analysis of the range of dermatological drugs with the antimicrobial and wound healing and / or anti-inflammatory effect for the complex treatment of wound superficial skin lesions (wounds, burns, scratches).

Materials and methods. Scientific and practical publications on the topic of the research were used. The State Register of Medicinal Products of Ukraine was used as an information source for research; the period of analysis was the IV quarter of2019. In the segment studied the products with the specified pharmacological activities were included. According to the ATC-classification they belong to the following subgroups: D03A – preparations that promote healing (scarring) of wounds; D08A – Antiseptic and disinfectants. D06 subgroup products – antibiotics and chemotherapeutics for dermatological use were not subject to the analysis.

Results. The analysis of the range of dermatological drugs inUkraine has been conducted, semi-solid medicines have been studied; it has been determined that the drugs presented are mostly of synthetic origin. Herbal medicines are represented by only a few names. The studies have also shown that these drugs possess a hydrophobic base, which has its disadvantages. In this regard, a promising dosage form is an emulgel, which combines the softening properties of a semi-solid dosage form due to the presence of the oil phase.

Conclusions. According to the results of the study, the nomenclature of dermatological drugs has been studied, and the expediency of creating a new drug in the form of an emulgel based on the dry extract of Scutellaria has been substantiated. The new drug will provide an effective therapeutic effect on the second and third phases of the wound-healing process since it promotes complete release of the active substances and their penetration into the tissues, prevents the secondary infections, protects the granulation tissue from mechanical damages, as well as activates the course of the wound process, reduces microbial contamination of wounds and creates conditions for epithelialization of the wound surface.


Keywords


Ukrainian market; semisolid dosage form; emulgel; antibacterial

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References


Andrukh, V. S., Andrukh, V. N. (2017). On the rational use of antibiotics in the modern world: a focus on paediatrics. Modern paediatrics, 3 (83), 10–15.

Bondar, M. V., Pilipenko, M. M., Svintukovsky, M. Yu., Kharchenko, L. A., Prevysla, O. M., Zwick, I. M. (2016). Antibiotic resistance of microorganisms: mechanisms of development and ways of prevention. Emergency Medicine, 3, 11–17.

Khameneh, B., Iranshahy ,M., Soheili, V., Fazly Bazzaz, B. S. (2019). Review on plant antimicrobials: a mechanistic viewpoint. Antimicrob. Resist. Infect. Control., 8 (118). Available at: https://aricjournal.biomedcentral.com/articles/10.1186/s13756-019-0559-6 (Accessed : 01.11.2019).

Iakovlieva, L. V., Tkachova, O. V., Kalf–Kalif, S. S. (2001). Study of reparative action of new wound healing ointments of natural origin. Bulletin of Pharmacy, 3 (27): Modern Problems of Pharmaceutical Science and Practice : mat. Research Practice Conf., 123–124.

Rukhmakova, O. A., Yarnykh, T. G., Maloshtan, L. M., Yatsenko, O. Y., Zeghdani, EZ. A. (2015). Justification for rational concentration of active substances of ointment for treatment of allergic dermatitis complicated by fungal infection. Topical issues in pharmaceutical and medical science and practice, 2 (18), 75–77.

Kotvitska, A. A., Korobova, E. S. (2016). Assessment of economic availability of antibacterial drugs for treating acute simple bronchitis in children under the age of three years. Social pharmacy in health care, 2 (4), 24–31. Available at: http://nbuv.gov.ua/UJRN/sphhc_2016_2_4_6 (Accessed: 01.11.2019).

Iakovlieva, L. V., Matiashova, N. O. (2013). ABC–analysis of antibacterial agents. Management, Economics and Quality Assurance in Pharmacy, 2 (28), 94–99.

Simonian, L. S. (2017). Marketing research of the pharmaceutical market of antibacterial drugs used in the treatment of hospital pneumonia. Management, economics and quality assurance in pharmacy, 1, 50–56. doi: 10.24959/uekj.17.2.

Gadiak, I.V., Grom, O. L., Komar, A. V. (2011). Monitoring the Market for Antibacterial Drugs in the Macrolide Group. Pharmaceutical Journal, 1, 19–24. – Available at: http://nbuv.gov.ua/UJRN/pharmazh_2011_1_5 (Accessed: 01.11.2019).

Shmatenko, A. P., Solomenny, A. M., Podlisny, O. V., Orlova, N. M. (2018). Marketing research of the market of infusion medicines and antibiotics for optimization of stocks used in the treatment of wounded servicemen in the area of joint forces operation. Collection of scientific works of employees of NMAPE after P. L. Shupik, 30, 436–447. Available at: http://nbuv.gov.ua/UJRN/Znpsnmapo_2018_30_43 (Accessed : 01.11.2019).


GOST Style Citations


1.  Andrukh, V. S. On the rational use of antibiotics in the modern world: a focus on paediatrics / V. S. Andrukh, V. N. Andrukh // Modern paediatrics. – 2017. – No. 3 (83). – P. 10–15.

 

2.  Antibiotic resistance of microorganisms: mechanisms of development and ways of prevention / M. V. Bondar, M. M. Pilipenko, M. Yu. Svintukovsky, L. A. Kharchenko, O. M. Prevysla,I.M. Zwick // Emergency Medicine. – 2016. – No. 3. – P. 11–17.

 

3.  Review on plant antimicrobials: a mechanistic viewpoint / B. Khameneh, M. Iranshahy, V. Soheili, B. S. Fazly Bazzaz // Antimicrob. Resist. Infect. Control. –2019. – No. 8 (118). – Available at: https://aricjournal.biomedcentral.com/articles/10.1186/s13756-019-0559-6 (Accessed: 01.11.2019).

 

4.  Iakovlieva, L. V. Study of reparative action of new wound healing ointments of natural origin / L. V. Iakovlieva, O. V. Tkachova, S. S. Kalf–Kalif // Bulletin of Pharmacy. – 2001. – No. 3 (27) : Modern Problems of Pharmaceutical Science and Practice : mat. Research Practice Conf. – P. 123–124.

 

5.  Justification for rational concentration of active substances of ointment for treatment of allergic dermatitis complicated by fungal infection / O. A. Rukhmakova, T. G. Yarnykh, L. M. Maloshtan, O. Y. Yatsenko, EZ. A. Zeghdani // Topical issues in pharmaceutical and medical science and practice. – 2015. – No. 2 (18). – P. 75–77.

 

6.  Kotvitska, A. A. Assessment of economic availability of antibacterial drugs for treating acute simple bronchitis in children under the age of three years / A. A. Kotvitska, E. S. Korobova // Social pharmacy in health care. – 2016. – Vol. 2, No. 4. – P. 24–31. – Available at: http://nbuv.gov.ua/UJRN/sphhc_2016_2_4_6 (Accessed: 01.11.2019).

 

7.  Iakovlieva, L. V. ABC–analysis of antibacterial agents / L. V. Iakovlieva, N. O. Matiashova // Management, Economics and Quality Assurance in Pharmacy. – 2013. – No. 2 (28). – P. 94–99.

 

8.  Simonian, L. S. Marketing research of the pharmaceutical market of antibacterial drugs used in the treatment of hospital pneumonia / L. S. Simonian // Management, economics and quality assurance in pharmacy. – 2017. – No. 1. – P. 50–56. doi : 10.24959/uekj.17.2.

 

9.  Gadiak, I. V. Monitoring the Market for Antibacterial Drugs in the Macrolide Group / I. V. Gadiak, O. L. Grom, A. V. Komar // Pharmaceutical Journal. – 2011. – No. 1. – P. 19–24. – Available at: http://nbuv.gov.ua/UJRN/pharmazh_2011_1_5 (Accessed: 01.11.2019).

 

10.  Marketing research of the market of infusion medicines and antibiotics for optimization of stocks used in the treatment of wounded servicemen in the area of joint forces operation / A. P. Shmatenko, A. M. Solomenny, O. V. Podlisny, N. M. Orlova // Collection of scientific works of employees of NMAPE after P. L. Shupik. – 2018. – Issue. 30. – P. 436–447. – Available at: http://nbuv.gov.ua/UJRN/Znpsnmapo_2018_30_43 (Accessed: 01.11.2019).





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Abbreviated key title: Soc. pharm. health care

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