The scientific substantiation of the rational technology of the fungal biomass cultivation for the prevention and complex therapy of immunological and oncological diseases
Keywords:industrial production of dry powder, cultivation, biomass, biotechnology, Coriolus versicolor fungus
Cancer and worsening of the immune status of the population still remain one of the most common causes of death among the population of Ukraine and many countries around the world. This is primarily due to socio-political, economic and other reasons that lead to the suppression of the immune system, which performs the main protective functions of the general resistance of the human body to infectious diseases. Despite the effective pharmacotherapeutic role of chemotherapy when treating cancer of various etiologies, most drugs cause toxic effects directly on healthy cells, and the genotoxic effect of chemotherapeutic drugs leads to the generation of secondary malignancies. In this aspect, new medicinal substances from medicinal fungi deserve special attention. Intensive development of mycological biotechnology is due to the high interest in the study and practical application of biotherapeutic drugs based on basidiomycetes. Numerous components of the fungal biomass of Coriolus versicolor stimulate and strengthen the body as a whole, and, at the same time, its protective and restorative functions. The prolonged use of this natural raw material increases the body’s resistance to oncopathology, stimulates the immune system. Thus, considering the above it is important to develop scientific and practical approaches of an antitumor and immunostimulatory drug based on Coriolus versicolor and its implementation in the pharmaceutical industry; it is a solution to the problem of treating immunocompromised patients.
Aim. To develop the scientifically substantiated and rational technology for cultivation of the fungal biomass of Coriolus versicolor for the immunocorrector prevention and complex therapy of immunological and oncological diseases.
Materials and methods. Such methods as physico-chemical, technological, microbiological were used. The studies on the selection of the medium for the biomass cultivation of Coriolus fungi were conducted at the premises of the М. G. Kholodnyi Institute of Botany of the National Academy of Sciences of Ukraine (Kyiv).
Results. The selection of the medium for the biomass cultivation, drying, grinding, and the sieve analysis were determined; the biotechnological flowchart for industrial production of a dry powder was developed.
Conclusions. The study has revealed that biotechnology based on the use of a yeast-like culture of Coriolus versicolor can be adapted to the conditions of the existing microbiological production in our country; the biomass and exocellular polysaccharide can be used as substances for the manufacture of therapeutic and prophylactic drugs.
Fedotov, O., Bisko, N. (2018). Effect of Phenolic Substances and Hydrogen Peroxide on Antioxidant Activity of Some Strains of Basidiomycetes. Innovative Biosystems and Bioengineering, 2 (1), 4-10. doi: https://doi.org/10.20535/ibb.2018.2.1.124101.
Lomberg, M. L., Mikhailova, O. B., Bisko, N. A. (2015). Mushroom culture collection IBK as a subject of national heritage of Ukraine. Ukrainian Botanical Journal, 72 (1), 22-28. doi: https://doi.org/10.15407/ukrbotj72.01.022.
Кlechak, I., Bisko, N., Syroid, O. (2019). Research on the Possibility of Biotechnological Using Wastes of Fruit and Vegetable Products as a Substrate for Lentinula edodes. Innovative Biosystems and Bioengineering, No. 3 (4), 212-219. doi: https://doi.org/10.20535/ibb.2019.3.4.170648.
Klechak, I. R., Bisko, N. A., Mytropolska, N. Yu., Antonenko, L. O. (2014). Naukovi visti Natsionalnoho tekhnichnoho universytetu Ukrainy, 3, 52-57. Available at: http://old.bulletin.kpi.ua/2014-3-8.
Antonenko, L. O., Klechak, I. R. (2012). Proceeding from Kharchuvannia yak profilaktychnyi ta likuvalnyi faktor v suchasnykh ekolohichnykh umovakh: Materialy naukovo-praktychnoi konferentsii (16-21 sichya 2012). (pp. 38–41). Kyiv: Nauka.
Wasser, S. P., Sytnik, K. M., Buchalo, A. S. (2002). Medicinal mushrooms: past, present and future. Ukrainian Botanical Journal, 5, 499-524.
Antonenko, L. O., Trokhymenko, O. P., Klechak, I. R. (2012). Naukovi pratsi Natsionalnoho universytetu kharchovykh tekhnolohii, 42, 29-34.
Klechak, R. I., Antonenko, L. O., Nyshporska, O. I. (2008). Proceeding from Biotekhnolohiia XXI stolittia: Materialy II naukovo-praktychnoi konferentsii studentiv ta aspirantiv (23-25 kvitya 2008). Kyiv: Nauka.
Antonenko, L. O., Klechak, I. R. (2011). Vostochno-evropeiskyi zhurnal peredovykh tekhnolohyi, 6/6 (54), 4-13. Available at: http://journals.uran.ua/eejet/article/view/2288/2092.
Cui, J., Chisti, Y. (2003). Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production. Biotechnology advances, 21, 109-122. doi: https://doi.org/10.1016/S0734-9750(03)00002-8.
Klechak, I. R., Mytropolska, N. Yu., Antonenko, L. O., Nyshporska, O. I. (2009). Naukovi visti NTUU “KPI”, 1 (63), 128-133. Available at: http://old.bulletin.kpi.ua/2009-1-18.
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